Clear Tartarus region (stage 1).

Clear Asphodel region (stage 2).

Clear Elysium region (stage 3).

Clear at least one escape attempt.

Use Greater Call at least once, any Olympian God counts.

Unlock all Infernal Arms (all weapons). 

• Stygian Blade (unlock by default).
• Eternal Spear: requires 4 Chthonic Keys.
• Shield of Chaos: requires 3 Chthonic Keys.
• Heart-Seeking Bow: requires 1 Chthonic Key.
• Twin Fists: requires 8 Chthonic Keys after unlocked Eternal Spear, Shield of Chaos, and Heart-Seeking Bow.
• Adamant Rail: requires 8 Chthonic Keys after other weapons are unlocked.

Fulfill the 'Chthonic Colleagues' Prophecy.

• Meet Lord Hades
• Meet Nyx
• Meet Charon
• Meet Thanatos
• Meet Hypnos
• Meet Megaera
• Meet Alecto
• Meet Tisiphone
• Meet Primordial Chaos

Beat Thanatos by 15 kills or more. Simply try to kill as many as soon as possible when Thanatos comes to help you.

Slay Skelly 15 times, pretty straightforward. 

Buy 9 'Well of Charon' items in one escape attempt, pretty straightforward too.

Pet Cerberus 10 times, this one is very easy.

Trade 20 times with the Wretched Broker. This is pretty easy too, the Wretched Broker in the Lounge. 

Earn access to and enter the Administrative Chamber, unlock as you progress the story.

Max at least one of any Weapon Aspect.

Compel Orpheus to sing again. Keep talking to Orpheus whenever he has exclamation mark on his head until he sings again.

Forge a bond with any character. In order to forge a bond with a character, you'll have to give them Nectar. At one point, you'll have to give them Ambrosia instead until the Heart Gauge max out.

Catch a fish from each region, pretty straightforward, although you'll have to purchase Rod of Fishing from House Contractor so that you can fish.

Pay for 50 jobs from the House Contractor, basically, you purchase 50 times from the House Contractor.

Complete the main quest in the story. Keep escaping from the underworld until you see the end credit.

Fulfill any 15 Prophecies (The Fated List).

Choose 50 different Daedalus Hammer enchantments. There is shortcut for this one, so keep choosing new weapon and upgrade every time until you receive the achievement.

Earn a Loyalty Card. To earn the card, you'll have to fight Charon and win because he is a secret boss. In order to trigger the fight, you'll have to steal (pick up) a sake of gold behind him but the sake of gold appears randomly in any shop except the one before the boss fight.

Equip a Chthonic Companion. There are 6 Companions in the game each can be unlocked by fully forge a bond (giving Nectar and Ambrosia) with the following 6 characters:

• Megaera (Battie)
• Thanatos (Mort)
• Sisyphus & Bouldy (Shady)
• Skelly (Rib)
• Dusa (Fidi)
• Achilles & Patroclus (Antos)

Fulfill the 'Master of Arms' Prophecy. To fulfill the Master of Arms prophecy, you'll have to escape at least once with all the weapons:

• Stygian Blade
• Eternal Spear
• Shield Of Chaos
• Heart-seeking Bow
• Twin Fists
• Adamant Rail

Clear an escape attempt with a hidden Weapon Aspect.

Unlock each standard Keepsake. Keep giving Nectar and Ambrosia to all characters, when fully forged the bond, they'll give you the Keepsakes.

Clear an Infernal Gate without taking damage, the easiest way to do this is with range weapons like Shield or Bow.

Fully Unlock the Olympians' Codex entries, this can be a very long process to obtain. You can check your Codex when you are in the House of Hades.

Fulfill the 'War-God's Bloodlust' Prophecy. 
Condition: Slay 10,000 foes or more, then talk to Ares.

Clear Elysium region with the 'Extreme Measures' Condition. First, you'll to have successfully escaped at least once to unlock the Pact of Punishment. Then, increase Extreme Measures to 3 and clear the Elysium region.

Fulfill the 'Musician and Muse' Prophecy. The objective is to find a way to reunite Orpheus and Eurydice, simply keep talking to Orpheus and Eurydice whenever possible as the story progress.

Get 20% dodge chance with the Lambent Plume, First, you'll have to obtain the Lambent Plume from Hermes by fully forge a bond with him, then go to Keepsake and equip Lambent Plume and start the escape by clearing chambers as fast as possible until the Dodge rate reach 20%.

Earn the first of Skelly's prizes. First, unlock the Pact of Punishment by successfully escaped once, then by increasing difficulty in Pact of Punishment until the Heat reach level 8. Then, interact with the pillars covered by a blanked near the escape entrance.

Use an Olympian's Greater Call against them in a Trial. A little bit tricky, but first, you'll have to obtain Greater Call Boon from an Olympian god. After that, you'll have to find a chamber with 2 Boons that has the Olympian god who gave you the Greater Call Boon. Choose the other god so that you can fight against the one who gave you the Boon. Once you clear the trial, exit chamber and you'll receive the achievement. 

Purge a Legendary Boon. 

Fulfill the 'Slashed Benefits' Prophecy. Simply enable "Benefits Packager" in the Pact of Punishment and escape multiple times, until you unlock the achievement. 

Have at least one rank in each Mirror of Night Talent. Require a little of Darkness grinding until you can afford to upgrade each one of them.

Fulfill the 'Night and Darkness' Prophecy. The prophecy is to find a way to reunite Nyx and Chaos. 

• Purchase "Administrative Privilege" from House Contractor.
• Keep giving Nectar and Ambrosia to Nyx and Chaos.
• Keep talking to Nyx and Chaos until Nyx asks you to restore Eldest Sigil.
• Purchase a Work Order from House Contractor to repair the Sigil. 
• Talk to Nyx again to complete the prophecy.

Fulfill the 'End to Torment' Prophecy by finding a way to pardon Sisyphus. Sisyphus can be found in Tartarus region randomly.

• Purchase "Administrative Privilege" from House Contractor.=
• Once you find him, keep giving Nectar to him.
• When you have given enough Nectar, a dialogue pops up that Zagreus wants to do something to help him.
• Then keep talking to Megaera and Hades until conversion about Sisyphus is mentioned.
• Talk to Nyx to reveal the contract location in the Administration room.
• Go there and find, then purchase Knave-King's Sentence from House Contractor.

Unlock all Weapon Aspects.

Fulfill the 'Dark Reflections' Prophecy. Basically, you'll have to unlock all Mirror of Night talents, then successfully escape with each one of the talents enabled. They don't have to be enabled at in one attempt.

Fulfill the 'Divided by Death' Prophecy. Find a way to reunite Achilles and Patroclus. Patroclus can be found randomly in Elysium region. You goal is to keep talking and giving Nectar to him and everyone else involve, following the dialogue and complete some side quests until Hades allows Achilles to meet Patroclus. This is very similar to "End of Torment" achievement.

Reach the epilogue of the story. This one requires you to complete the entire story of Hades. Even after the credit, there are still story to progress. 

Fulfill the 'Harsh Conditions' Prophecy. Escape the underworld with all of Pact of Punishment enabled, they don't have to be enabled all at once.

Earn the second of Skelly's prizes. The first prize requires 8 Heat and the second one requires 16 Heat level.

Get 30% bonus damage with the Pierced Butterfly. First, keep giving Nectar and Ambrosia to Thanatos until you obtain Pierced Butterfly from him. Then equip the Pierced Butterfly from Keepsakes and try your best to clear at least 10 chambers without taking damage. Tip: try with long range weapons can help a lot.

Earn all Chthonic Companions. See Rare Collectible achievement.

Max-rank each standard Keepsake.